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Aniseikonia is a condition in which the sizes of retinal images do not match one another. In most cases, it is associated with anisometropia, but is sometimes caused by the layout of the retina’s receptors. For the purposes of this article, we will assume that aniseikonia is either refractive or axial.

Like most ametropias, there are two main causes, these being axial and refractive. In the case of axial aniseikonia, the refractive power of the eye is normal but it is the length of the eye that causes the image to either form in the front or the back of the retina. In the case of refractive aniseikonia, the length of the eye is normal but its refractive power may either be too weak or too strong, again placing the image in front or behind the retina. Interestingly, it is suggested that both conditions, axial and refractive aniseikonia, are better treated by different methods. In the case of simple refractive errors like hyperopia and myopia, both refractive and axial conditions can either be treated with the use of spectacles or contact lenses. With aniseikonia it is suggested that refractive should be treated with contact lenses, while axial should be treated with spectacles. This is known as Knapp’s Law.

Knapp’s Law states that a lens placed before an eye with axial ametropia will produce an image that is the equivalent of an emetropic eye. A contact lens, on the other hand, will create magnification, which would be desirable for the treatment of refractive aniseikonia. However Knapp’s Law is imperfect and many feel that it’s not quite appropriate for actual clinical use. It’s difficult to tell whether the ametropia is completely axial or refractive, or a combination of the two. Knapp’s Law does also not apply to aniseikonia caused by the layout of the retina’s receptors.

In an attempt to help equalize image size, a style of lens fabrication is used to create an iseikonic lens. In the design of an iseikonic lens, the magnification can be manipulated without affecting the lens’ refractive power. The determining factors in spectacle magnification are 1) base curve 2) vertex distance 3) thickness. With these three factors, the designer can adjust each of these values to determine the best design. But first we must determine the difference in image size.

 

“Knapp’s Law states that a lens placed before an eye with axial ametropia will produce an image that is the equivalent of an emetropic eye. A contact lens, on the other hand, will create magnification, which would be desirable for the treatment of refractive aniseikonia."

     

EXAMPLE:
A patient comes in with significant aniseikonia and requires an iseikonic lens.

First we need to determine the size difference caused by the lens. 
This is done with the spectacle lens magnification formula.

SM = 1/1- (t/n) D1 x 1/ 1-hD

t - thickness 
n - index of refraction 
D1 - base curve 
D - actual power 
h - vertex distance + 3mm (must be converted to meters) 
^ - change in value

Our above patient has the following prescription:

OD + 4.00 sph
OS + .75 sph

And is wearing lenses made to the following specifications
Lens index - 1.498 Vertex distance - 14m
Base curves - OD = 9.00 OS = 6.00
Thickness - OD = 5mm OS = 2mm

Using the above formula, we will calculate the percentage of spectacle magnification.

1/1-(0.005/1.498)(9.00)  x  1/1-(.017)(.75)

1/1-.0300400  x  1/1-.01275  

(1.03097)(1.01291)=1.044

(1.044-1) 100= 4.4%

 

Now the same is done for the left eye (for the sake of space we will not do the left eye here). Once the left eye is done you subtract the percentage of the right eye from the left and this gives you the magnification difference.

Now how do we reduce this percentage? As mentioned earlier, we can control the amount of magnification by changing the base curve, center thickness and vertex distance. These are a few formulas that will help calculate which changes are needed.

  • ^%SM = ^D1 t/h  To calculate base curve changes.

  • ^%SM = ^D1 t/h  To calculate thickness changes.

  • ^%SM = ^h D/10  To calculate vertex distance.

In the case of a hyperope with anisometropia, frame selection is very, very important. Remember that thickness can increase magnification and in the case of a hyperope, the larger the frame, the thicker the center of the lens, creating more magnification! A case in point may be an anisometropic hyperope who wants a small fashionable frame for work, but desires a large coverage sunglass to protect his sensitive eyes while enjoying the outdoors. He may not feel too comfortable about the vision in his sunglasses compared to his dress glasses. This may be due to the increased magnification created by the extra thickness required in a larger frame.

In reality people have a very large tolerance of both anisometropia and aniseikonia and do not always require slab off or iseikonic lenses. However, it is something that can be a useful tool for EyeCare professionals. By trying to understand these conditions, it helps make the EyeCare professional a little more knowledgeable about concepts such as prismatic effect, image size, spectacle magnification, axial and refractive ametropia, and the importance of base curves, thickness, vertex distance and proper frame selection.

    Donn McCarthy
dandmoptical@hotmail.com